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GHK exhibits a Cu 2+ affinity comparable to that of albumins copper transport sites, forming an in vivo complex, glycyl-L-histidyl-L-lysine-Cu 2+ (GHK-Cu), which enhances its bioavailability (Pickart, 2008)

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GHK-Cu can sting, especially at higher concentration, but it is not the same problem as NAD+ acidity or SS-31/MOTS-c cationic welting

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